Good afternoon and thank you for the invitation to address you today. Nowadays it feels very strange to be in front of a live audience, instead of a screen. Three years ago, when I spoke at this conference, the world was a different place. When the COVID-19 crisis started, we all said that everything was different. Two years later, everything is different again. Trying to figure out these ‘new differents’ certainly feels like I’m lost in the multiverse or my daughter’s version of the ‘upside-down world’.